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The LFA-1 adhesion molecule is involved in cell adhesion events of leukocytes through binding to ICAM-1, ICAM-2 and ICAM-3.
Interestingly, we observed that LFA-1/ICAM-1 co-stimulation of T cells resulted in high production of the Th2 cytokine IL-10 compared to ICAM-2 or ICAM-3 co-stimulation.
In contrast, ICAM-2 and ICAM-3 induced a much stronger secretion of the Th1 cytokine TNF-α compared to LFA-1/ICAM-1 induced co-stimulation, despite the lower proliferation rate.